Predicting real-world emotion and health from spontaneously assessed linguistic distancing using novel scalable technology.

Individuals who are better at regulating their emotions have been shown to have better physical and mental health outcomes. One promising emotion regulation strategy is psychological distancing, which involves appraising a stimulus with objectivity or spatial/temporal distance. Language-based psychological distancing (linguistic distancing [LD]) refers to the degree to which one implements psychological distancing naturally via language. A crucial, underexamined mechanism that may account for real-world emotion and health self-reports is spontaneous (i.e., implicit) LD. Using HealthSense, a novel, scalable, mobile health assessment application, we collected lexical transcriptions for personally specific negative and positive events as well as emotion and health-relevant data over 14 days (data collected in 2021) and examined how implicit LD during negative and positive events relates to well-being over time. Primary analyses revealed that higher LD during negative events was associated with lower levels of stress as well as greater emotional and physical well-being within persons. LD during positive events on 1 day predicted greater reports of happiness 2 days later within persons. LD during positive events was associated with fewer symptoms of depression and LD during negative events was associated with greater physical well-being among persons. Exploratory analyses revealed that average depression, rumination, and perceived stress across the 2 weeks were significantly negatively associated with LD during negative events between persons. The present results expand understanding of the relationship between LD and mental and physical health risks and motivate future research on low-burden, scalable interventions involving LD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Lexical markers of cognitive reappraisal, bereavement, and proinflammatory cytokine production.

OBJECTIVE: The loss of a spouse is considered one of the most significant life change-related stressors. Bereaved spouses have significantly increased risk of chronic inflammation, and ultimately greater morbidity and mortality. High levels of proinflammatory cytokines are related to negative health outcomes. In bereavement, the ability to successfully regulate emotion is a vital skill for healthy coping and may represent a key psychological mechanism accounting for varying degrees of resilience. Psychological distancing is a frequently adaptive emotion regulation strategy in which an individual appraises a negative situation by taking a step back and distancing oneself, and coolly evaluates what is happening. The objective of the present work was to investigate whether psychological distancing, implemented implicitly via natural language use (i.e., linguistic distancing [LD]), is related to inflammation and bereavement-related health indicators. METHOD: Participants (N = 144) underwent a blood draw for the inflammation assay, completed questionnaire measures evaluating grief symptoms and health, and completed an oral task describing their relationship with their deceased spouse, which was used for the lexical analyses. RESULTS: We found that LD was significantly associated with a panel of a priori proinflammatory stimulated cytokines (TNF-α, IL-6, IFN-γ, IL-17A, and IL-2), bereavement-related health indices, and the relationship between grief symptoms and inflammation varied depending on the participants' implementation of LD. CONCLUSIONS: LD may have a buffering effect for this vulnerable population. This work elucidates novel dependencies among language, emotion, and health. This work identifies resilience factors and probes the translational value of LD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Novel computational algorithms to index lexical markers of psychological distancing and their relationship to emotion regulation efficacy over time.

The degree to which one employs an objective or spatially/temporally distant perspective via language, i.e., linguistic distancing, has previously been shown to be positively associated with well-being. We sought to further elucidate relationships among language and emotion over time as a function of the implementation of sub-tactics of psychological distancing. In Study 1, we developed novel deep machine learning algorithms to identify the degree to which linguistic patterns reflect two types of psychological distancing, namely objective (OBJ) and spatial/temporal (FAR) distancing. In Study 2, in an expressive writing-based longitudinal emotion regulation training task, participants transcribed their thoughts while viewing negative or neutral stimuli over 5 sessions in one of three ways: by implementing objective language (Objective group), by implementing spatially/temporally distant language (Far group), or by responding naturally. We found that the OBJ and FAR algorithms significantly predicted changes in task-based self-reported negative affect in the Objective group and found no significant associations in the Far group. The relationship between the algorithm scores and self-reported negative affect was stronger in the Objective group compared to the Far group. These findings describe sensitive linguistic distancing algorithms that are capable of tracking changes in self-reported negative affect. These results may be useful in developing novel, unobtrusive emotion regulation assessments and interventions that utilize natural language processing.

Cognitive reappraisal and nasal cytokine production following experimental rhinovirus infection.

Following exposure to the common cold (i.e., rhinovirus), locally produced nasal cytokines (rather than the infection itself) drive the progression of one's symptoms (Hendley et al., 1973; Cohen et al., 1999). Stress-induced local inflammation exacerbates local cytokine production (e.g., marital hostility; Kiecolt-Glaser et al., 2005). An individual's ability to effectively manage their emotions is a critical component of positive health and well-being. Here, we evaluated whether one's self-reported frequency of cognitive reappraisal, an adaptive emotion regulation strategy, predicts nasal cytokine production following experimental rhinovirus exposure. Emotion regulation strategies were assessed at baseline prior to experimental infection. After the baseline assessment, each participant was exposed to a strain of rhinovirus (RV-39) and followed for 5 days in quarantine. Nasal interleukin (IL)-1ß, IL-6, and IL-8 and subjective symptoms were assessed at baseline and on each of the 5 days of quarantine. A multilevel analysis of the data for 159 participants with documented infection demonstrated that less frequent use of cognitive reappraisal predicted heightened production of the nasal cytokine composite. Those who self-reported using cognitive reappraisal strategies less frequently displayed elevated nasal IL-6 and IL-8. Among the 63 participants with clinical cold, less frequent use of cognitive reappraisal was associated with heightened production of nasal IL-1ß, IL-6, and IL-8. In ancillary analyses, the composite of nasal cytokines was associated with the severity of one's subjective symptoms across the 5 days. Findings suggest that emotion regulation strategies, particularly cognitive reappraisal, influence illness trajectories during rhinovirus infection.

Connecting cognition, cardiology, and chromosomes: Cognitive reappraisal impacts the relationship between heart rate variability and telomere length in CD8+CD28- cells.

Individuals who poorly regulate emotion exhibit premature aging and worse general health. Telomere shortening, a prognostic biomarker of physical health, is related to aging, poor immunocompetence and autonomic nervous system functioning. Cognitive reappraisal is one type of emotion regulation strategy, which involves changing one's appraisal of an aversive situation to modify its emotional impact. Heart rate variability (HRV; i.e., oscillations in heart rate) relates to emotion regulatory processes, such that higher HRV typically reflects greater regulatory capacity. Previous research has identified a positive association between HRV and telomere length. Importantly, the association between HRV and telomere length may change depending on how often an individual uses cognitive reappraisal. One hundred and thirty-seven healthy participants completed measures of cognitive reappraisal frequency, HRV, and underwent blood draws to measure telomere length (computed with the relative ratio of telomere repeat copy number to single copy gene number) in the T cell effector population, CD8+CD28-. Cognitive reappraisal moderated the relationship between telomere length and HRV such that individuals with high cognitive reappraisal frequency had a significant positive association between HRV and telomere length, while individuals with average and less than average frequency did not exhibit this relationship. The results suggest that frequent usage of cognitive reappraisal enhances the already positive influence of HRV on chromosomal integrity in CD8+CD28- T lymphocytes. Although future research is needed to test these effects causally, these findings suggest that regularly using emotion regulation techniques may buffer the relationship between autonomic nervous system functioning and chromosomal integrity in immune cells.

Predicting emotional health indicators from linguistic evidence of psychological distancing.

Psychological distancing, a form of cognitive reappraisal, involves construal of emotionally valenced stimuli in an objective manner, or with perceived spatial and temporal distance. Prior work suggests that in appropriate contexts, reappraisal broadly, and distancing specifically, is related to adaptive mental and physical health outcomes. Additionally, recent research suggests that shifting language to be more distant (i.e., linguistic distancing [LD]) can have adaptive emotion regulatory effects. The present study addressed whether LD is also associated with adaptive health indicators. Participants transcribed their thoughts while viewing negative or neutral stimuli in one of three ways: (a) by implementing objective language, (b) by implementing spatially and/or temporally far away language, or (c) by responding naturally. Across psychological distancing groups, LD was associated with lower negative affectivity (lower perceived stress and depression symptoms), better general well-being (better emotional well-being and energy and vitality), and better emotion regulation (ER; greater reappraisal frequency and fewer difficulties in implementing ER). Participants who used more LD in the objective group had lower negative affectivity, better general well-being, and better ER, and those in the far group had better ER. The results reveal linguistic mechanisms underlying ER and its relationship to health indicators, suggesting future examination of LD interventions.

Implicit reappraisal as an emotional buffer: Reappraisal-related neural activity moderates the relationship between inattention and perceived stress during exposure to negative stimuli.

Emotion regulation often is an adaptive option in the face of elevated perceived stress. Perceived stress has been shown to have negative consequences for physical and mental health, including cognitive deficits and difficulties controlling attention. Cognitive reappraisal is an emotion regulation strategy that involves changing one's cognitive construal of an emotionally evocative stimulus to alter its emotional impact. Reappraisal can be implemented explicitly or implicitly (i.e., with or without conscious awareness). The objective of the present study was to examine whether implicit cognitive reappraisal during exposure to negative stimuli moderates the relationship between inattention and perceived stress. We found, as expected, that inattention problems are associated with increased perceived stress, but also found that one's spontaneous propensity to engage in cognitive reappraisal-as indexed by correspondence with a reliable thresholded whole-brain pattern of reappraisal implementation-moderated the relationship between inattention and perceived stress. Overall, the current study provides evidence that spontaneous reappraisal recruitment has a buffering effect on the relationship between inattention and perceived stress.

Grief, depressive symptoms, and inflammation in the spousally bereaved.

Grief is conceptualized by strong negative emotions, which include longing, sadness, and preoccupations with thoughts, recollections, and images of the spouse. In the initial months after the loss of a spouse, those who are widowed are at risk for cardiovascular problems and premature mortality. In the general population, depression is characterized by chronic low-grade inflammation, a key predictor of cardiovascular problems, morbidity, and mortality. Although depression and grief share similarities, they are distinct constructs. We aimed to identify if grief was related to inflammation among those who had a spouse recently die. We also sought to determine if those who are widowed and already experience elevated levels of depressive symptoms compared with the general population had higher levels of inflammation compared with those who are widowed who report fewer depressive symptoms. Ninety-nine recently bereaved individuals (M = 84.74 days since passing, SD = 18.17) completed a blood draw and psychological assessments. Proinflammatory T cell-derived cytokines were assessed, which included interferon gamma (IFN-γ), interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), IL17-A, and IL-2. Bereaved individuals with a higher grief severity (using an established cut-score) had higher levels of the proinflammatory cytokines IFN-γ, IL-6, and TNF-α than those with less grief severity. Those who experienced higher levels of depression exhibited elevated levels of proinflammatory cytokines compared with those who had lower levels of depression (using a continuous measure of depressive symptoms, as well as an established cut score). This is the first study to demonstrate that inflammatory markers can distinguish those who are widowed based on grief severity such that those who are higher on grief severity have higher levels of inflammation compared with those who are lower on grief severity. These findings also add to the broader literature on depression and inflammation by showing that even in a population with high levels of depressive symptoms, there is a positive relationship between depression and inflammation.

Mending the heart and mind during times of loss: A review of interventions to improve emotional well-being during spousal bereavement.

Spousal loss is one of life's greatest stressors. Bereaved spouses are at risk for aberrant cognitive and affective processing. Recent work in psychoneuroimmunology and cognitive neuroscience reveals physiological biomarkers and neural mechanisms underlying acute distress and grief during bereavement that may represent targets for future interventions. We review evidence from existing pharmacological and psychotherapeutic treatment approaches for normal bereavement, complicated grief, and bereavement-related depression. We propose promising future directions, namely the development and empirical validation of novel, personalised cognitive and neurostimulatory interventions to promote adaptive emotion regulation and reduce depressive symptoms following spousal loss. Future work may substantiate which interventions to improve emotional and physical health will be best matched to the needs of a particular surviving spouse.